using System;
using System.Collections.Generic;
using System.Linq;
using System.Text;

namespace ToWord
{
    class Program
    {
        static void Main(string[] args)
        {
            string sourceFile = @"c:\users\administrator\documents\visual studio 2012\Projects\ToWord\ToWord\WordModel.doc";
            string destFile = @"c:\users\administrator\documents\visual studio 2012\Projects\ToWord\ToWord\Model\WordModel.doc";
            //复制文件
            System.IO.File.Copy(sourceFile, destFile, true);
            WordOperate wordOperate = new WordOperate();

wordOperate.Open(destFile);
            wordOperate.Replace("[项目名标签]","神没什么项目的");
            wordOperate.Replace("[项目编号签]", "神没什么项目的");
            wordOperate.Save();
        }
    }
}

using System;
using System.Collections.Generic;
using System.Diagnostics;
using System.Linq;
using System.Text;

namespace ToWord
{
    public class WordOperate : IDisposable
    {
        private Microsoft.Office.Interop.Word._Application _app;
        private Microsoft.Office.Interop.Word._Document _doc;
        object _nullobj = System.Reflection.Missing.Value;

/// <summary>
        /// 关闭Word进程
        /// </summary>
        public void KillWinword()
        {
            var p = Process.GetProcessesByName("WINWORD");
            if (p.Any()) p[0].Kill();
        }

/// <summary>
        /// 打开word文档
        /// </summary>
        /// <param name="filePath"></param>
        public void Open(string filePath)
        {

_app = new Microsoft.Office.Interop.Word.ApplicationClass();
            object file = filePath;
            _doc = _app.Documents.Open(
                 ref file, ref _nullobj, ref _nullobj,
                 ref _nullobj, ref _nullobj, ref _nullobj,
                 ref _nullobj, ref _nullobj, ref _nullobj,
                 ref _nullobj, ref _nullobj, ref _nullobj,
                 ref _nullobj, ref _nullobj, ref _nullobj, ref _nullobj);
        }

        /// <summary>
        /// 替换word中的文字
        /// </summary>
        /// <param name="strOld">查找的文字</param>
        /// <param name="strNew">替换的文字</param>
        public void Replace(string strOld, string strNew)
        {
            //替换全局Document
            _app.Selection.Find.ClearFormatting();
            _app.Selection.Find.Replacement.ClearFormatting();
            _app.Selection.Find.Text = strOld;
            _app.Selection.Find.Replacement.Text = strNew;